Yildiz Lab

Eukaryotic cells rely on molecular motors to transport cargo along cytoskeletal tracks and maintain their internal organization. How motors recognize specific cargoes, regulate their activity, and deliver cargo to the correct destinations remains incompletely understood.​ Recent advances in biochemical reconstitution, cryo-electron microscopy, and single-molecule imaging now allow us to address these questions with unprecedented molecular detail. By combining high-resolution structural analysis with direct measurements of motor dynamics and force generation, we aim to uncover the molecular principles governing microtubule-based transport and its regulation.